منابع مشابه
Spliceosome Database: a tool for tracking components of the spliceosome
The spliceosome is the extremely complex macromolecular machine responsible for pre-mRNA splicing. It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly dynamic fashion. One important challenge to studying the spliceosome is simply keeping track of all these proteins, a situation further complicated by the variety of names and identifiers that exist in the ...
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Accurate quantification of gene expression by qRT-PCR relies on normalization against a consistently expressed control gene. However, control genes in common use often vary greatly between samples, especially in cancer. The advent of Next Generation Sequencing technology offers the possibility to better select control genes with the least cell to cell variability in steady state transcript leve...
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Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to regulate splicing. The majority of higher eukaryotic protein-coding genes contain more than one intron and the derived pre-mRNAs can be alternatively spliced. Diverse principles ensure the reliable identification of authentic splice sites while concomitantly providing flexibility in splice site ...
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The aim of this study is to investigate the use of the linguistic information present in the audio signal to structure broadcast news data, and in particular to associate speaker identities with audio segments. While speaker recognition has been an active area of research for many years, addressing the problem of identifying speakers in huge audio corpora is relatively recent and has been mainl...
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Voicemail is not like email. Even such basic information as the name of the caller/ sender or a phone number for returning calls is not represented explicitly and must be obtained from message transcripts or other sources. We discuss techniques for doing this and the challenges these tasks present.
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2018
ISSN: 1548-7091,1548-7105
DOI: 10.1038/s41592-018-0058-3